Central lateral thalamic neurons receive noxious visceral mechanical and chemical input in rats.

نویسندگان

  • Yong Ren
  • Liping Zhang
  • Ying Lu
  • Hong Yang
  • Karin N Westlund
چکیده

Thalamic intralaminar and medial nuclei participate mainly in affective and motivational aspects of pain processing. Unique to the present study were identification and characterization of spontaneously active neurons in the central lateral nucleus (CL) of the intralaminar thalamus, which were found to respond only to viscerally evoked noxious stimuli in animals under pentobarbital anesthesia. Responses to noxious colorectal distention, intrapancreatic bradykinin, intraperitoneal dilute acetic acid, and greater splanchnic nerve electrical stimulation were characterized. Electrophysiological recordings revealed activity in most CL neurons (93%) was excited (69%) or inhibited (31%) in response to noxious visceral stimulation of visceral nerves. Expression of c-Fos observed in CL nucleus after intensive visceral stimulation confirmed the activation. However, excited CL neurons did not have somatic fields, except in 3 of 43 (7%) CL neurons tested for responses to somatic stimulation (innocuous brush and noxious pinch). Intrathecal administration of morphine significantly reduced the increased responses of CL neurons to colorectal and pancreatic stimuli and was naloxone reversible. High-level thoracic midline dorsal column (DC) myelotomy also dramatically reduced responses, identifying the DC as a major route of travel from the spinal cord for CL input, in addition to input traveling ventromedially in the spinothalamic tract identified anatomically in a previous study. Spinal cord and lower brain stem cells providing input to medial thalamus were mapped after stereotaxic injections of a retrograde dye. These data combined with our previous data suggest that the CL nucleus is an important component of a medial visceral nociceptive system that may mediate attentional, affective, endocrine, motor, and autonomic responses to noxious visceral stimuli.

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منابع مشابه

Noxious Visceral Mechanical and Chemical Input in Rats

Running title: Central lateral thalamic nucleus responses to visceral input

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Recent discoveries of visceral nociceptive inputs sharing the classical tactile pathway in the dorsal-column medial lemniscus system have opened a new venue for the investigation of somatovisceral interactions. The current study was designed to determine whether somatic innocuous inputs modulate visceral nociceptive transmission at the thalamic level. The investigation was carried out by means ...

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Somatovisceral interactions in the rat dorsal column nuclei

Recent studies have revealed that noxious visceral inputs travel in the dorsal column pathway, and interactions between colorectal noxious and tactile inputs occur in the ventrobasal thalamus. This investigation was to test whether the somatovisceral interactions also take place in the dorsal column nuclei (DCN). Forty-five single DCN neurons of anesthetized rats responsive to colorectal disten...

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The effect of systemic cocaine on spontaneous and nociceptively evoked activity of neurons in the medial and lateral thalamus.

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عنوان ژورنال:
  • Journal of neurophysiology

دوره 102 1  شماره 

صفحات  -

تاریخ انتشار 2009